Noggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry

Noggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry 1 and Transient Receptor Potential Cation Channels 2 3 4 Kai Yang , Jing Jia, Jie Zhang, Mingming Zhao, Sabrina Wang, Haiyang Jiang, Lei Xu , 5 Wenju Lu and Jian Wang 2 6 7 Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Diseases, The 1 8 Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 510120; Division of 9 Pulmonary & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, 10 Maryland, United States, 21224; Laboratory of Molecular Biology and Immunology, National 11 Institute on Aging, Baltimore, Maryland, United States, 21224. 12 13 14 Corresponding Authors: 15 16 Jian Wang, MD or Wenju Lu, MD 17 Guangzhou Institute of Respiratory Diseases 18 State Key Laboratory of Respiratory Diseases 19 The First Affiliated Hospital 20 Guangzhou Medical University 21 151 Yanjiang Road, Guangzhou, Guangdong, 510120 22 People’s Republic of China 23 E-mail: [email protected] or [email protected] 24 25 Or 26 27 Jian Wang, MD 28 Division of Pulmonary and Critical Care Medicine 29 Johns Hopkins University School of Medicine 30 5501 Hopkins Bayview Circle, Rm. 4B30 31 Baltimore, MD 21224 32 Email: [email protected] 33 34 Running title: Noggin inhibits TRPC-SOCE signaling in PASMC 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50